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Progress and challenges in RET-targeted cancer therapy
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 207-219 doi: 10.1007/s11684-023-0985-y
Keywords: pralsetinib selpercatinib RET-alteration lung cancer thyroid cancer tumor-agnostic therapy drug
Gut microbial balance and liver transplantation: alteration, management, and prediction
Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng
Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 123-129 doi: 10.1007/s11684-017-0563-2
Keywords: gut microbial balance liver transplantation ischemia–reperfusion acute rejection
Frontiers of Medicine doi: 10.1007/s11684-023-1008-8
Keywords: 3D genome cancer TADs loop gene regulation
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 176-184 doi: 10.1007/s11684-021-0885-y
Keywords: small noncoding RNAs epigenetic inheritance paternal intergenerational inherence extracellular vesicles
Zhenhao Xu, Tengfei Yu, Peng Lin, Shucai Li
Engineering 2023, Volume 27, Issue 8, Pages 150-160 doi: 10.1016/j.eng.2022.09.013
Keywords: Mineral anomaly Adverse geology Fault Alteration Anomaly threshold
Fanfan Li, Mengzhou He, Meitao Yang, Yao Fan, Yun Chen, Xi Xia, Yin Xie, Dongrui Deng
Frontiers of Medicine 2018, Volume 12, Issue 5, Pages 542-549 doi: 10.1007/s11684-017-0576-x
Preeclampsia (PE) is a pregnancy-specific, multi-system disorder and the leading cause of maternal and perinatal morbidity and mortality in obstetrics worldwide. Excessive vasoconstriction and dysregulated coagulation function are closely associated with PE. Heat shock protein 20 (HSP20) is ubiquitously expressed under normal physiological conditions and has important roles in vascular dilatation and suppression of platelet aggregation. However, the role of HSP20 in the pathogenesis of PE remains unclear. In this study, we collected chorionic plate resistance arteries (CPAs) and serum from 118 healthy pregnant women and 80 women with PE and detected the levels of HSP20 and its phosphorylated form. Both HSP20 and phosphorylated HSP20 were downregulated in CPAs from women with PE. Comparison of the vasodilative ability of CPAs from the two groups showed impaired relaxation responses to acetyl choline in preeclamptic vessels. In addition to the reduced HSP20 in serum from women with PE, the platelet distribution width and mean platelet volume were also decreased, and the activated partial thromboplastin time and thromboplastin time were elevated. With regard to the vital roles of HSP20 in mediating vasorelaxation and coagulation function, the decreased HSP20 might contribute to the pathogenesis of PE.
Keywords: preeclampsia heat shock protein 20 vascular relaxation coagulation-fibrinolytic system
Title Author Date Type Operation
Gut microbial balance and liver transplantation: alteration, management, and prediction
Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng
Journal Article
Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer
Journal Article
Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational
Journal Article
Adverse Geology Identification Through Mineral Anomaly Analysis During Tunneling: Methodology and Case Study
Zhenhao Xu, Tengfei Yu, Peng Lin, Shucai Li
Journal Article